Hy's law

Hy's law is a prognostic indicator that a pure drug-induced liver injury (DILI) leading to jaundice, without a hepatic transplant, has a case fatality rate of 10% to 50%. The law is based on observations by Hy Zimmerman, a major scholar of drug-induced liver injury.[1]

Hy’s Law cases have the following three components

As defined by The U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER) Center for Biologics Evaluation and Research (CBER) in their final document of 2009 Guidance for Industry Drug-Induced Liver Injury: Premarketing Clinical Evaluation.

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